Unloved and unwanted, orphan Pollyanna Whittier boards an eastbound train to live with her Aunt Polly, a wealthy spinster. Aunt Polly treats the child insensitively, giving her a musty room in the attic and expecting her to keep quiet and stay out of the way. Pollyanna, with her optimistic outlook on life, turns all the lemons thrown her way into lemonade; punishments are viewed as rewards, unfriendly people in town are befriended. Pollyanna's "Glad Game" is soon played by all the people of the town.

A terrible accident with a motor car as she is crossing the street finally breaks Pollyanna's spirit. When long-held secrets are finally revealed, even Aunt Polly comes around to warming up not only to her niece, but to a relationship she had long denied herself. A beloved and classic tale follows the adventures of an optimistic young girl who transforms the lives of the somber adults she encounters with her persistent faith in the "glad game."