Texas Rangers August McCrae and Woodrow Call, now in their middle years, continue to deal with the ever-increasing tensions of adult life -- Gus with his great love, Clara Forsythe, and Call with Maggie Tilton, the young woman who loves him. Two proud but very different men, they enlist with the Ranger troop in pursuit of Buffalo Hump, the great Comanche war chief; Kicking Wolf, the celebrated Comanche horse thief; and a deadly Mexican bandit king with a penchant for torture. Assisting the Rangers in their wild chase is the renowned Kickapoo tracker, Famous Shoes.

Comanche Moon closes the twenty-year gap between Dead Man's Walk and Lonesome Dove, following beloved heroes Gus and Call and their comrades in arms -- Deets, Jake Spoon, and Pea Eye Parker -- in their bitter struggle to protect the advancing West frontier against the defiant Comanches, courageously determined to defend their territory and their way of life.

"Comanche Moon" is described as the final volume of the "Lonesome Dove" saga although chronologically it is the second of the four novels, taking place between "Dead Man's Walk" and "Lonesome Dove".