When Sarah McClure and her husband, Matt, move to the small town of Waterford, Pennsylvania, to get a fresh start, Sarah struggles to find a fulfilling job. Disheartened by failed interviews, she reluctantly accepts a temporary position at Elm Creek Manor helping seventy-five-year-old Sylvia Compson prepare her family estate for sale after the recent death of Sylvia's estranged sister. As part of her compensation, Sarah is taught how to quilt by this reclusive, cantankerous master quilter.

During their lessons, Mrs. Compson slowly opens up to Sarah, sharing powerful, devastating stories of her life as a young woman on the World War II home front. Hearing tales of how Mrs. Compson's family was torn apart by tragedy, jealousy, and betrayal, Sarah is forced to confront uncomfortable truths about her own family -- truths that she has denied for far too long. As the friendship between the two women deepens, Mrs. Compson confides that although she would love to remain at her beloved family estate, Elm Creek Manor exists as a constant, unbearable reminder of her role in her family's misfortune. For Sarah, there can be no greater reward than teaching Mrs. Compson to forgive herself for her past mistakes, restoring life and joy to her cherished home.

As each woman adds a border to the central block, she contributes her story to the ongoing history of Elm Creek Manor. Resplendent in green, blue, and gold, the quilt serves as a symbol of the complex, lasting ties that unify mothers and daughters, sisters and friends. As they stitch together the sometimes harmonious, often discordant scraps of their crazy-quilt lives, the Elm Creek Quilters learn that friendship is a most precious gift, and that even in the darkest of times, love illuminates the way home.

Megan is a successful engineer who has won prizes for her miniature quilt designs. The one challenge she has yet to master is single motherhood. Donna, a mother of two, must hasten to teach her daughter independence and self-esteem -- lessons she, too, must take to heart. Grace is a renowned curator of antique quilts, whose creative flair is waning for reasons she is unwilling to reveal -- even to her closest friends. Vinnie, the senior member of the group, is a sunny soul with a tragic past. Her overwhelming desire is to bring happiness into the lives of those she loves.

Although the Cross-Country Quilters share a common creative goal, as the year goes by their bonds are tested by the demands of daily life. But despite differences in age, race, and background, the friends' love for quilting and affection for one another unite them in a patchwork of caring and acceptance. The quilt they make reminds them of an everlasting truth -- friends may be separated by great distance, yet the strength of their bond can transcend any obstacle.